Drawing on case studies from the Republic of Korea, Thailand, and Viet Nam, this publication highlights successful strategies, mechanisms, and innovations in early coronavirus disease (COVID-19) pandemic response in Asia and the Pacific. Across the region, diverse approaches are being taken to mitigate COVID-19. The case studies presented here focus on analyzing pandemic-related challenges in the context of universal health coverage. They identify and describe good practices and lessons learned in emergency and crisis planning, management, and coordination along with whole-of-government and whole-of-society approaches to pandemic response.